Publicaciones

2017

2016

2015

2014

2013

2012

  • Nock A, Ascano JM, Barrero MJ, Malik S. (2012) Mediator-regulated transcription through the +1 nucleosome. Mol Cell 48(6):837-48. Epub 2012 Nov 15.
  • Berniakovich I, Laricchia-Robbio L, Izpisua Belmonte JC. (2012) N-acetylcysteine protects induced pluripotent stem cells from in vitro stress: impact on differentiation outcome. Int J Dev Biol 56(9): 729-35.
  • Mateo S, Parriego M, Boada M, Vidal F, Coroleu B, Veiga A. (2012) In vitro development and chromosome constitution of embryos derived from monopronucleated zygotes after intracytoplasmic sperm injection. Fertil Steril Dec 13. [Epub ahead of print].
  • Izpisúa Belmonte JC. (2012) Reprogramming development and aging: cell differentiation as a malleable process. Curr Opin Cell Biol 24(6): 713-5. [Epub ahead of print].
  • Mo Li, Juan Carlos Izpisua Belmonte. (2012) No factor left behind: generation of transgene-free induced pluripotent stem cells. Am J Stem Cells 1(1):75-80.
  • Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte JC, Matsui Y. (2012) Cell cycle gene- specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 26(22): 2477-82.
  • Jopling C, Suñè G, Faucherre A, Fabregat C, Izpisua Belmonte JC. (2012) Hypoxia Induces Myocardial Regeneration in Zebrafish. Circulation 126(25):3017-27. Epub 2012 Nov 14.
  • Yang SL, Harnish E, Leeuw T, Dietz U, Batchelder E, Wright PS, Peppard J, August P, Volle-Challier C, Bono F, Herbert JM, Izpisúa Belmonte JC. (2012) Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesisProtein Cell 3(12):934-42. Epub 2012 Nov 17.
  • Guang-Hui Liu, Jing Qu, Keiichiro Suzuki, Emmanuel Nivet, Mo Li, Nuria Montserrat, Fei Yi, Xiuling Xu, Sergio Ruiz, Weiqi Zhang, Ulrich Wagner, Audrey Kim, Bing Ren, Ying Li, April Goebl, Jessica Kim, Rupa Devi Soligalla, Ilir Dubova, James Thompson, John Yates III, Concepcion Rodriguez Esteban, Ignacio Sancho-Martinez & Juan Carlos Izpisúa Belmonte. (2012) Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature 491(7425):603-7. Epub 2012 Oct 17.
  • Masuda S, Izpisua Belmonte JC. (2012) Trametinib for patients with advanced melanoma. Lancet Oncology (10): e409
  • Ruiz S, Panopoulos AD, Montserrat N, Multon MC, Daury A, Rocher C, Spanakis E, Batchelder EM, Orsini C, Deleuze JF, Izpisua Belmonte JC. (2012) Generation of a drug-inducible reporter system to study cell reprogramming in human cells.
    J Biol Chem 287(48):40767-78. Epub 2012 Sep 27.
  • Liu GH, Ding Z, Izpisua Belmonte JC. (2012) iPSC technology to study human aging and aging-related disorders. Curr Opin Cell Biol 24(6):765-74. Epub 2012 Sep 18.
  • Ruiz, S, Diep, D, Goreb, A, Panopoulos, AD, Montserrat, N, Plongthongkumb, N, Kumara, S, Fung, HL, Giorgetti, A, Bilic, J, Batchelder, EM, Zaehres, H, Kan, NG, Schöler, HR, Mercola, M, Zhang, K, and Izpisua Belmonte JC. (2012)
    Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. P Natl Acad Sci USA 109(40):16196-201. Epub 2012 Sep 18.
  • Murphy DA, Diaz B, Bromann PA, Tsai JH, Kawakami Y, Maurer J, Stewart RA, Izpisúa-Belmonte JC, Courtneidge SA. (2012) Correction: A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development.
    PLoS One 7(8)
  • Sancho-Martinez I, Baek SH, Izpisua Belmonte JC. (2012) Lineage conversion methodologies meet the reprogramming toolbox.
    Nat Cell Biol 14(9): 892-9
  • Zhang K, Yi F, Liu GH, Izpisúa Belmonte, JC. (2012) Huntington's disease: Dancing in a dish.
    Cell Res 22 (12): 1627-30. Epub 2012 Aug 7.
  • Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. (2012) Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells.
    Cell Stem Cell 11(2):242-52
  • Li M, Liu GH and Izpisúa Belmonte JC. (2012) Navigating the epigenetic landscape of pluripotent stem cells.
    Nat Rev Mol Cell Biol
    13(8): 524-35
  • Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH and Izpisúa Belmonte JC. (2012) Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. P Natl Acad Sci USA 109(31):12556-61. Epub 2012 Jul 18.
  • Yi F, Qu J, Li M, Suzuki K, Kim NY, Liu GH and Izpisúa Belmonte JC. (2012) Establishment of hepatic and neural differentiation platforms of Wilson's disease specific induced pluripotent stem cells.
    Protein Cell J3(119: 855-63. Epub 2012 JUl. 18.
  • Masuda S, Monserrat N, Okamura D, Suzuki K and Izpisúa Belmonte JC. (2012) Cardiosphere-derived cells for heart regeneration.
    Lancet 379(9835): 2425-6.
  • Arán B, Solé M, Rodriguez-Pizà I, Parriego M, Muñoz Y, Boada M, Barri PN, Izpisúa Belmonte JC and Veiga A. (2012) Vitrified blastocysts from Preimplantation Genetic Diagnosis (PGD) as a source for human Embryonic Stem Cell (hESC) derivation.
    J Assist Reprod Genet  29(10): 1013-20. Epub 2012 Juny 27.
  • Cai N, Li M, Qu J, Liu GH and Izpisúa Belmonte JC. Post-translational modulation of pluripotency. J Mol Cell Biol 4(4):262-5. Epub 2012 Jun 7.
  • Christen B, Cavaco Rodrigues AM, Barragán Monasterio M, Fabregat Roig C and Izpisúa Belmonte JC. Transient downregulation of Bmp signalling induces extra limbs in vertebrates.
    Development 139(14): 2557-65.
  • Barrero MJ, Berdasco M, Paramonov I, Bilic J, Vitaloni M, Esteller M and Izpisúa Belmonte JC. DNA Hypermethylation in Somatic Cells Correlates with Higher Reprogramming Efficiency.
    Stem Cells
    30(8): 1696-702.
  • Gu Y, Liu GH and Izpisúa Belmonte JC. (2012) Gametogenesis in a dish.
    Cell Res 22(10):1422-5. Epub 2012 May 29.
  • Letamendia A, Quevedo C, Ibarbia I, Virto JM, Holgado O, Diez M, Izpisúa Belmonte JC and Callol-Massot C. Development and validation of an automated high-throughput system for zebrafish in vivo screenings.
    PLoS One
    7(5): e36690.
  • Montserrat N, Ramirez-Bajo MJ, Xia Y, Sancho-Martinez I, Moya-Rull D, Miquel-Serra L, Yang S, Nivet E, Cortina C, Gonzalez F, Izpisúa Belmonte JC and Campistol JM. (2012) Generation of induced pluripotent stem cells from human renal proximal tubular cells with only two transcription factors: OCT4 and SOX2.
    J Biol Chem
    287(29):24131-8. Epub 2012 May 21.
  • Panopoulos AD and Izpisúa Belmonte JC. Induced pluripotent stem cells in clinical hematology: potentials, progress, and remaining obstacles.
    Curr Opin Hematol 
    19(4): 256-60.
  • Liu GH, Yi F, Suzuki K, Qu J and Izpisúa Belmonte JC. Induced neural stem cells: a new tool for studying neural development and neurological disorders.
    Cell Res
    22(7): 1087-91.
  • Vassena R, Montserrat N, Canal BC, Aran B, de Oñate L, Veiga A and Izpisúa Belmonte JC. Accumulation of instability in serial differentiation and reprogramming of parthenogenetic human cells.
    Hum Mol Genet
    21(15): 3366-73.
  • Xu X, Qu J, Suzuki K, Li M, Zhang W, Liu GH and Izpisúa Belmonte JC.  Reprogramming based gene therapy for inherited red blood cell disorders.
    Cell Res
    22(6): 941-4. 
  • Yi F, Liu GH and Izpisúa Belmonte JC. Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy.
    Protein Cell
    3(4): 246-50.
  • Jopling C, Suñé G, Morera C and Izpisúa Belmote JC. p38α MAPK regulates myocardial regeneration in zebrafish.
    Cell Cycle
    11(6): 1195-201.
  • Liu GH, Li M, Qu J and Izpisúa Belmonte JC. Gating neural development and aging via nuclear pores.
    Cell Res
    22:1212-1214. Epub 2012 Mar 13.
  • Yi F, Liu GH and Izpisúa Belmonte JC. Rejuvenating liver and pancreas through cell transdifferentiation.
    Cell Res
    22(4): 616-9.
  • Cavaco Rodrigues AM, Christen B, Marti M and Izpisúa Belmonte JC.  Skeletal muscle regeneration in Xenopus tadpoles and zebrafish larvae.
    BMC Dev Biol 12(1): 9.
  • Montserrat N, Aran B and Izpisúa Belmonte JC. Cellules Mare Embrionàries: Què en Sabem Després de Trenta Anys D'Investigacio?
    Treballs de la SCB 63: 215-233.
  • Bilic J and Izpisúa Belmonte JC. Concise review: induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart?
    Stem Cells 30(1): 33-41.
  • Liu G-H, Sancho-Martinez I and Izpisúa Belmonte JC. Cut and Paste: restoring cellular function by gene correction.
    Cell Research 22(2): 283-4.
  • Menendez S, Camus S, Herreria A, Paramonov I, Batlle Morera L, Collado M, Pekarik V, Maceda I, Edel M, Consiglio A, Sanchez A, Li H, Serrano M and Izpisúa Belmonte JC. Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency.
    Aging Cell
    11(1): 41-50.
  • Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerías A, Batchelder EM, Plongthongkum N, Lutz M, Berggren WT, Zhang K, Evans RM, Siuzdak G and Izpisúa Belmonte JC. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming.
    Cell Res
    22(1): 168-77.
  • Sanchez-Danes A, Consiglio A, Richaud Y, Rodriguez-Piza I, Dehay B, Edel M, Bove J, Memo M, Vila M, Raya A and Izpisua Belmonte JC.  Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and iPS cells.
    Human Gene Therapy 23(1): 56-69.
  • Fütterer A, Raya A, Llorente M, Izpisúa Belmonte JC, de la Pompa JL, Klatt P and Martínez-A C. Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development.
    Cell Death Differ. 19(1): 132-43.
  • Giorgetti A, Montserrat N, Izpisúa Belmonte JC. (2012) Induced Pluripotent Stem Cells (iPSC) from Cord Blood CD133+ Cells Using Oct4 and Sox2. In K. Ye & S. Jin (Eds.), Human Embryonic and Induced Pluripotent Stem Cells. Lineage-Specific Differentiation Protocols. Springer Protocol Handbook Series (pp 93-111). New York, NY: Humana Press.

2011

  • Camus S, Quevedo C, Menéndez S, Paramonov I, Stouten PF, Janssen RA, Rueb S, He S, Snaar-Jagalska BE, Laricchia-Robbio L and Izpisúa Belmonte JC. Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish.
    Oncogene Dec 19. [Epub ahead of print]
  • Tiscornia G, Lorenzo Vivas E and Izpisúa Belmonte JC. Diseases in a Dish: modeling human disease with induced pluripotent stem cells.
    Nature Medicine 6: 1570-1576.
  • Li M, Suzuki K, Qu J, Saini P, Dubova I, Yi F, Lee J, Sancho-Martinez I, Liu GH and Izpisúa Belmonte JC. Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs.
    Cell Res 21(12): 1740-4.
  • Sancho-Martinez I, Nivet E and Izpisúa Belmonte JC. The labyrinth of nuclear reprogramming.
    J Mol Cell Biol
    3(6): 327-9.
  • Sancho-Martinez I, Nivet E and Izpisúa Belmonte JC. Purging and isolating pluripotent cells, "sweet" dreams become true?
    Cell Res
    21(11): 1526-7.
  • Montserrat N, de Oñate L, Garreta E, González F, Adamo A, Eguizábal C, Häfner S, Vassena R and Izpisúa Belmonte JC. Generation of feeder free pig induced pluripotent stem cells without Pou5f1.
    Cell Transplant
    Sep 23. [Epub ahead of print]
  • Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, Sahara S, O’Leary DDM, Nakagawa Y, Lewandoski M, Pfaff S, Evans SM and Izpisúa Belmonte JC. Islet1-mediated activation of the beta-catenin pathway is necessary for hindlimb initiation in mice.
    Development 138: 4465-4473. 
  • Terme JM, Sese B, Millan-Arino L, Mayor R, Izpisúa Belmonte JC, Barrero MJ and Jordan A. Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency.
    J Biol Chem 286(41): 35347-57.
  • Panopoulos AD and Izpisúa Belmonte JC. Anaerobicizing into pluripotency.
    Cell Metab 14(2): 143-4.
  • Murphy DA, Diaz B, Bromann PA, Tsai JH, Kawakami Y, Maurer J, Stewart RA, Izpisúa Belmonte JC and Courtneidge SA. A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development.
    PLoS ONE
    6(7): e22499.
  • Vassena R, Boué S, González-Roca E, Aran B, Auer H, Veiga A and Izpisúa Belmonte JC. Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development.
    Development 138(17): 3699-709.
  • Eguizabal C, Montserrat N, Vassena R, Barragan M, Garreta E, Garcia-Quevedo L, Vidal F, Giorgetti A, Veiga A and Izpisúa Belmonte JC. Complete Meiosis from Human Induced Pluripotent Stem Cells.
    Stem Cells 29(8):1186-95.
  • Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC and Izpisúa Belmonte JC. Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs.
    Cell Stem Cell 8(6): 688-94.
  • Adamo A, Sesé B, Boue S, Castaño J, Paramonov I, Barrero MJ and Izpisúa Belmonte JC. LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.
    Nat Cell Biol 13(6): 652-60.
  • Panopoulos AD, Ruiz S, Yi F, Herrerías A, Batchelder EM and Izpisúa Belmonte JC. Rapid and Highly Efficient Generation of Induced Pluripotent Stem Cells from Human Umbilical Vein Endothelial Cells.
    PLoS ONE 6(5): e19743.
  • Giorgetti A, Fazzina R, Li M and Izpisúa Belmonte JC. Human cord blood reprogrammed into embryonic-like stem cells.
    ISBT Science Series 6: 107-111.
  • Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage FH and Verma IM.  Brief report: Efficient Generation of Hematopoietic Precursors and Progenitors From Human Pluripotent Stem Cell Lines.
    Stem Cells 29(7): 1158-64.
  • Robles V, Martí M and Izpisúa Belmonte JC. Study of Pluripotency Markers in Zebrafish Embryos and Transient Embryonic Stem Cell Cultures.
    Zebrafish 8(2): 57-63.
  • Barrero MJ and Izpisúa Belmonte JC. iPS cells forgive but do not forget.
    Nat Cell Biol 13(5): 523-5.
  • Menchón C, Edel MJ and Izpisúa Belmonte JC. The cell cycle inhibitor p27Kip1 controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist.
    Cell Cycle 10(9): 1435-47.
  • Edel MJ, Menchon C, Andres Vaquero JM and Izpisúa Belmonte JC. A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells.
    Cell Commun Signal 9(1): 8.
  • Panopoulos AD, Ruiz S and Izpisúa Belmonte JC. iPSCs: Induced Back to Controversy.
    Cell Stem Cell  8(4): 347-8.
  • Tiscornia G, Monserrat N and Izpisúa Belmonte JC. Modelling Long QT Syndrome With iPS Cells: Be Still, My Beating Heart ...
    Circ Res 108(6): 648-9.
  • Sancho-Martinez I, Li M and Izpisúa Belmonte JC. Disease Correction the iPSC Way: Advances in iPSC-Based Therapy.
    Clin Pharmacol Ther 89(5): 746-9.
  • Kim S and Izpisúa Belmonte JC. Pluripotency of male germline stem cells.
    Mol Cells 32(2): 113-121.
  • Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisúa Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS and Zhang K. Somatic coding mutations in human induced pluripotent stem cells.
    Nature 471 (7336): 63-7.
  • Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Iii JY and Izpisúa Belmonte JC. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.
    Nature  472(7342): 221-5.
  • González F, Boué S and Izpisúa Belmonte JC. Methods for making induced pluripotent stem cells: reprogramming à la carte.
    Nat Rev Genet 12(4): 231-42.
  • Barrero MJ and Izpisúa Belmonte JC. Regenerating the epigenome.
    EMBO Rep 12(3): 208-15.
  • Montserrat N, Garreta Bahima E, Gonzalez F, Gutierrez J, Eguizabal C, Ramos Perez V, Borros S and Izpisúa Belmonte JC. Simple generation of human induced Pluripotent stem cells using Poly({beta}-Amino Esters) as non-viral gene delivery system.
    J Biol Chem 286(14): 12417-28.
  • Jopling C, Boue S and Izpisúa Belmonte JC. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.
    Nature Reviews Molecular Cell Biology 12: 79-89.
  • Li M, Sancho-Martinez I and Izpisúa Belmonte JC. Cell fate conversion by mRNA.
    Stem Cell Res Ther 2(1): 5.
  • Oishi I, Kim S, Yoshi K, Rodriguez Esteban C and Izpisúa Belmonte JC. Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells.
    BMC Biotechnology 11(1): 5.
  • Montserrat N, Bahima EG, Batlle L, Häfner S, Rodrigues AM, González F and Izpisúa Belmonte JC. Generation of Pig iPS Cells: A Model for Cell Therapy.
    J Cardiovasc Transl Res  4(2): 121-30.
  • Laurent LC, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, Lynch C, Harness JV, Lee S, Barrero MJ, Ku S, Martynova M, Semechkin R, Galat V, Gottesfeld J, Izpisúa Belmonte JC, Murry C, Keirstead HS, Park H, Schmidt U, Laslett AL, Muller F, Nievergelt CM, Shamir R and Loring JF. Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture.
    Cell Stem Cell 8: 106–118.
  • Ruiz S, Panopoulos AD, Herrerías A, Bissig KD, Lutz M, Berggren WT, Verma IM and Izpisúa Belmonte JC. A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity.
    Curr Biol 21(1): 45-52.

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