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A CMR[B] – IDIBELL research paper is selected by Stem Cell Reports among the best in its field

A CMR[B] – IDIBELL research paper is selected by Stem Cell Reports among the best in its field

The research article “ Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson’s Disease ”, co-led by CMR[B] researchers of Dr Angel Raya’s team and Dr. Antonella Consiglio’s team at the Bellvitge Biomedical Research Institute (IDIBELL), has been selected by the prestigious journal Stem Cell Reports to be part of their annual “ Best of ” compilation. The study was selected on the basis of reader download data, which editors feel to be the most unbiased way to guage interest in specific papers.

In the featured article, researchers prove that defective versions of human brain cells called astrocytes are linked to the buildup of α -synuclein, a toxic protein that is one the hallmarks of Parkinson's disease. These astrocytes, derived from Parkinson's disease patients with a genetic mutation that affects cell cleanup functions, cause a higher accumulation of the toxin than those derived from healthy individuals. The work, which appeared in Stem Cell Reports on January 10th, suggests an important role for glial cells in Parkinson's disease and offers potential new targets for developing therapies.

Stem Cell Reports Best of 2018-2019 ” is a reprint collection from Cell Press that highlight top research and reviews of Stem Cell Reports, the official, high-impact journal of the International Society for Stem Cell Research (ISSCR). This special issue is always published in conjunction with the Annual Meeting of the Society.

## This work was supported by the European Research Council-ERC, the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III, AGAUR, and CERCA Programme / Generalitat de Catalunya.

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